The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model
نویسندگان
چکیده
منابع مشابه
The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model
MicroRNA is a class of noncoding RNAs able to base pair with complementary messenger RNA sequences, inhibiting their expression. These regulatory molecules play important roles in key cellular processes including cell proliferation, differentiation and response to DNA damage; changes in miRNA expression are a common feature of human cancers. To gain insights into the mechanisms involved in brea...
متن کاملmiR-205 is involved in metastatic potential of 21T series, a breast cancer progression model
Methods To gain insights into the mechanisms involved in breast cancer initiation and progression we conducted a miRNA global expression on 21T series. These cell lines represent an in vitro model of breast cancer progression comprising immortalized cell lines derived from the same patient diagnosed with Her-2 overexpressing ductal carcinoma. The set include a normal epithelia (16N), primary in...
متن کاملMicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer
MicroRNAs (miRNAs) are a class of highly conserved, small endogenous single-strand non-coding RNAs. They are aberrantly expressed in the circulation and tissue of patients with cancer. Therefore, it has been suggested that they may act as key regulators of carcinogenesis. The aim of the present study was to examine the expression level of miR-195-5p in human breast cancer and its potential role...
متن کاملMetastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation.
Most cancer lethality is caused by metastasis. To gain insight into the molecular basis of tumor progression to metastasis, we used the 21T series of human mammary epithelial cells obtained by successive biopsies from one breast cancer patient. The c-erbB2 gene is amplified and overexpressed in each of three 21T tumor lines. The erbB receptor tyrosine kinase-activated phosphatidylinositol 3-kin...
متن کاملDepends on Akt/Protein Kinase B Activation Metastatic Potential of 21T Human Breast Cancer Cells
Most cancer lethality is caused by metastasis. To gain insight into the molecular basis of tumor progression to metastasis, we used the 21T series of human mammary epithelial cells obtained by successive biopsies from one breast cancer patient. The c-erbB2 gene is amplified and overexpressed in each of three 21T tumor lines. The erbB receptor tyrosine kinase–activated phosphatidylinositol 3-kin...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0173756